Running Head: S1PR1 agonism attenuates lung ischemia-reperfusion injury
نویسندگان
چکیده
2 Sphingosine-1-phosphate receptor 1 agonism attenuates 3 lung ischemia-reperfusion injury 4 5 6 7 Matthew L. Stone, Ashish K. Sharma, Yunge Zhao, Eric J. Charles, William F. Johnston, 8 Irving L. Kron, Kevin R. Lynch and Victor E. Laubach 9 10 11 12 Departments of Surgery and Pharmacology, University of Virginia, Charlottesville, VA 13 14 15 16 17 18 19 20 21 22 23 Running Head: S1PR1 agonism attenuates lung ischemia-reperfusion injury 24 25 26 Corresponding Author: Victor E. Laubach, PhD 27 Department of Surgery 28 University of Virginia 29 P.O. Box 801359 30 Charlottesville, VA 22908 31 Email: [email protected] 32 33 34 35 36 Articles in PresS. Am J Physiol Lung Cell Mol Physiol (April 24, 2015). doi:10.1152/ajplung.00302.2014
منابع مشابه
Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury.
Outcomes for lung transplantation are the worst of any solid organ, and ischemia-reperfusion injury (IRI) limits both short- and long-term outcomes. Presently no therapeutic agents are available to prevent IRI. Sphingosine 1-phosphate (S1P) modulates immune function through binding to a set of G protein-coupled receptors (S1PR1-5). Although S1P has been shown to attenuate lung IRI, the S1P rece...
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